Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with ...

Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...

The superfamily 1 (SF1) and SF2 enzymes are non-hexameric enzymes possessing both helicase and single-stranded DNA (ssDNA) translocase activities, as well as the ability to displace proteins from DNA.

Researchers in this field recently met to examine progress and outstanding issues. Helicases are molecular motors that couple nucleotide (NTP) binding and hydrolysis to nucleic acid (DNA or RNA ...

By binding uniquely to the helicase domain of WRN, IDE275 (GSK959) delivers potent and selective inhibition across MSI-H models," said Michael White, Ph.D., Chief Scientific Officer, IDEAYA ...

The achievement is not only a milestone in helicase research, but also a milestone in observing the dynamics of any enzyme at atomic resolution. While scientists have long known the importance of ...