In biology, reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development or in cell culture. [1] . Such control is also often …

HSCI Principal Faculty member Konrad Hochedlinger, PhD, and colleagues have recently shown two ways to substantially improve the odds of successfully creating iPS cell lines: selecting …

Direct reprogramming (also known as transdifferentiation) refers to a change in cell fate that, unlike in indirect reprogramming, does not involve a pluripotent intermediate state (usually the …

Jun 4, 2025 · Cell reprogramming is the process of reverting mature, specialised cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re …

Mar 27, 2025 · Cell reprogramming represents a powerful approach to achieve the conversion cells of one type into cells of another type of interest, which has substantially changed the …

Aug 24, 2023 · Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate and generate desired cell types including pluripotent stem cells for applications in …

Dec 13, 2024 · Cell reprogramming is the act of reverting mature, specialised cells into induced pluripotent stem cells, also known as iPS cells. This process requires a stem or progenitor cell …

During cellular reprogramming, a cell is induced to change its identity and function, using tools and methods that don't naturally occur in the context of and organism during its development …

This review discusses the scientific framework that led to the reprogramming of induced pluripotent stem cells (iPSCs), the roles of the OSKM in reprogramming the mature …

Reprogramming is the result of large-scale changes in the epigenetic profile and gene-expression pattern of a cell, induced by the over-expression of key transcription factors, which regulate …