C&EN1mon
Long-Range Electrostatics in Serine Proteases: Machine Learning-Driven Reaction Sampling Yields Insights for Enzyme Design
Institute for Drug Discovery, Leipzig University Medical School, Brüderstraße 34, Leipzig 04103, Germany Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Leninskie Gory ...
Frontiers1mon
Genome-Wide Transcription Start Site Mapping and Promoter Assignments to a Sigma Factor in the Human Enteropathogen Clostridioides difficile
Table 1. Sigma factors encoded in the genome of C. difficile strain 630. Figure 2. Examples of cleavage sites detected by TSS-mapping. Representative examples of 5′-end RNA-seq (TAP-/TAP+ profile ...
Frontiers4mon
Editorial: tRNA and protein synthesis in microorganisms
Protein synthesis is a central process in microorganisms and is heavily targeted by antimicrobials. Studies of transfer RNAs (tRNAs), aminoacyl-tRNA synthetases (aaRSs), and ribosomes have led to ...
eLife3y
Molecular architecture of the human tRNA ligase complex
RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase complex (tRNA-LC) ...
eLife4y
Translation in amino-acid-poor environments is limited by tRNA Gln charging
In addition to GCN2 activation and reduced total translation, the reduced charging of tRNA Gln in amino-acid-deprived cells also leads to specific depletion of proteins containing polyglutamine tracts ...