These two amino acids, methionine and leucine, are known activators of a signaling molecule called mTOR (short for "mammalian target of rapamycin"). Leptin-sensitive animals showed no such ...

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

As an illustration, blocking the PI3K/AKT/mTOR pathway may enhance autophagy, consequently preventing the activation of microglia [39]. In this study, we also found that overexpression of SIRT1 could ...

Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...

Furthermore, lysosome-targeted therapies have shown promise in hematological malignancies, particularly leukemia, where they induce cytotoxic effects on leukemia cells (Table 1). In T-ALL cells, ...

Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, Nadia, West Bengal 741246, India ...

The results also reveal how protein levels of ephrin receptor tyrosine kinase B4 (EphB4) — a factor that binds to InsRβ and facilitates its endocytosis and degradation in lysosomes — were ...

Optimizing clear cell renal cell carcinoma tumor-infiltrating lymphocytes under controlled hypoxic conditions. Association of KIM-1 with PFS and OS in metastatic RCC. Multivariable models are adjusted ...

1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan. 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical ...