An appeals court judge denied the Trump administration’s request for an administrative stay to block a court order that required federal agencies to lift their spending freezes—the latest blow to the Trump administration amid a slew of legal actions as Democrats and others fight President Donald Trump and cost-cutting czar Elon Musk in court.

Sen. Susan Collins (R-Maine) slammed the National Institutes of Health’s decision to slash billions of dollars in “indirect” costs for biomedical research funding, calling the move mandated by the Trump administration “devastating” and a “poorly conceived directive.”

This is the first time in President Donald Trump’s second term that a federal judge has accused his administration of defying a court order.

A Boston-based appeals court ruled on Tuesday that Trump is still barred for now from freezing federal grants, loans and other financial assistance.

President Donald Trump’s blanket freeze of federal spending hit another stumbling block Tuesday when a federal appeals court refused an emergency bid by his administration to lift the restrictions. The decision,