Amyotrophic lateral sclerosis (ALS) is a relatively rare but very serious disease of the nervous system. A cure is not yet ...

Complex protein interactions at synapses are essential for memory formation in our brains, but the mechanisms behind these processes remain poorly understood. Now, researchers have developed a ...

Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

The Pathways Development Camp (PDC) is a great stepping stone towards the U.S. national teams. PDC will help rowers develop their technique in small boats and learn or improve their sculling skills.

This important computational study investigates homeostatic plasticity mechanisms that neurons may employ to achieve and maintain stable target activity patterns. The work extends previous analyses of ...

Understanding the complex network and signaling pathways governing protein translation ... which inhibits translation of target RNAs within processing bodies (P-bodies). Stimulation of cAMP signaling ...

This study further explored the anti-CIRI mechanism of arctigenin via the EPO/EPOR-JAK2-STAT5 signaling pathway. Methods: TTC and H&E staining were used to observe infarct volume and morphological ...

Department of Chemistry, NC State University, Raleigh, North Carolina 27695, United States ...