The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

Types of insulin include rapid-, regular-, intermediate-, and long-acting, based on how long they take to start working. You may take a combination of these when managing type 2 diabetes.

Tyrosine kinase inhibitors (TKIs) have become increasingly important in the treatment of multiple cancers. They basically work by blocking signaling pathways that drive tumor growth in cancer.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China ...

Here, the kinase partners with TOM and VDAC, forming a supersized complex that tethers PINK1 to the outer membrane—a crucial first step toward clearing these defective organelles. The study appeared ...

Inactive conformations of protein kinase catalytic domains where the DFG motif has a ... targeted by FDA-approved ‘type-II inhibitors’ in the treatment of cancers. Tyrosine kinases (TKs) typically ...

Despite these differences, many lung cancer cells contain mutations that over-activate two molecular cascades called the MAP kinase and the PI3’-kinase pathways. Under normal conditions, these ...

Despite the wealth of available information regarding the activation by Akt, there remains a paucity of information regarding the cellular mechanisms that lead to Akt inactivation. In general, the ...