However, when the kidneys are no longer working—referred to as kidney failure—urea can accumulate to toxic levels. Uremia is most often due to kidney failure from advanced chronic kidney ...

The kidney is a major site of organ damage caused by drug toxicity. This frequently manifests during drug development and/or in standard clinical care. Nephrotoxicity resulting from drug exposure ...

the risk for toxicity is low. People who are most at risk usually either have an underlying condition that affects kidney function or are taking medications or supplements with a very high dose.

Fundamentally understanding why some antibiotics turn out to be toxic is now a major step closer, thanks to a €1.5 million grant awarded to biochemist Markus Weingarth.

KIBRA’s name comes from its location in the kidney and in the brain ... despite not fixing the problem of toxic tau protein accumulation,” said Kristeen Pareja-Navarro, co-first author of the study.