C&EN16d
Synergistic Antitumor Immunotherapy via Mitochondria Regulation in Macrophages and Tumor Cells by an Iridium Photosensitizer
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, ...
Frontiers24d
TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells
This study investigated the role of TIPE2 in regulation of CD4 + T lymphocyte function in interaction of PHSML and TLR2/TLR4. Methods: The splenic CD4 + T cells were isolated from various mice (WT, ...
Frontiers1mon
Progress in understanding Legg–Calvé–Perthes disease etiology from a molecular and cellular biology perspective
TLR4 belongs to the TLR family and is primarily expressed ... and pro-inflammatory monocytes can differentiate into osteoclasts, playing a role in bone resorption. Scholars found that in necrotic bone ...
eLife11mon
Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast–osteoblast communication and potential clinical implications
Bone remodeling is a complex process involving the coordinated actions of osteoblasts and osteoclasts to maintain bone homeostasis. While the influence of osteoblasts on osteoclast differentiation is ...
eLife4y
Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis
The enhanced bone resorption in Def6-/-mice dominates, leading to osteoporosis. Mechanistically, Def6 inhibits the differentiation of both osteoclasts and osteoblasts via a common mechanism through ...