Nuvalent Inc. has identified proto-oncogene tyrosine-protein kinase ROS (ROS1; MCF3) and/or ALK tyrosine kinase receptor inhibitors reported to be useful for the treatment of cancer.

Zai Lab's repotrectinib label expansion accepted in China for treating advanced solid tumors with NTRK gene fusion.

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

Tyrosine kinase inhibitors (TKIs ... Milciclib is a pan-CDK inhibitor that targets multiple CDKs, tropomyosin receptor kinases, and Src family kinases, which are involved in cancer cell growth and ...

The PI3K/Akt/mTOR signaling pathway is activated by G protein-coupled receptors and receptor tyrosine kinases through ligands such as growth factors, hormones, or cytokines. These receptors recruit ...

Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, China; ...

The human PIK3CA gene codes for the catalytic subunit of the ubiquitously expressed phosphoinositide 3-kinase alpha (PI3Kα), an enzymatic complex that is crucial for transducing signals from growth ...

EGFR is one of four members of the ErbB family of receptor tyrosine kinases that have key roles in development and the progression of many cancers. EGFR functions by activating many intracellular ...

Cells have proteins called receptors on their surface that can bind to specific molecules on the outside of the cell. Typically, this binding activates the receptor and the activated receptor then ...