Total revenue of $59.3 million for the fiscal year ended December 31, 2024Expect double digit growth for total revenue in 20252025 to demonstrate ...

Abstract: The Parkin RBR E3 Ubiquitin Protein Ligase gene, the second largest gene within the ... gene is approximately 1,300,000 base pairs (bp), while one of its messengers RNA (mRNAs) measures only ...

An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates. A single inhibitory upstream open reading frame ...

Adding these methyl groups enhances RNA stability; however ... Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 ...

Adding these methyl groups enhances RNA stability; however ... Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 ...

FTO drew attention in the field of obesity even before its role in RNA modification was fully understood ... proteins is mediated by E3 ubiquitin ligases, the team further investigated and ...

They say that change takes time. Well, that's not the case for RNA. The small biological molecule acts like a switchboard operator, capable of changing its shape every few milliseconds so it can ...

United States Center for RNA Technologies and Therapeutics, University of California San Diego, La Jolla, California 92037, United States Chemical Genomics Centre, Max Planck Institute of Molecular ...

So far, many ubiquitin E3 ligases anchored in the membrane system have been identified as critical players facilitating intracellular biofunctions whose dysfunction is highly related to cancer. In ...

RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase complex (tRNA-LC) ...