Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

For this, they designed an artificial ribozyme, R3C ligase, to investigate how individual RNA units come together to form a functional structure. Their work is published in the journal Life.

Within the NTase domain is an adenylate binding pocket composed of the six peptide motifs (I, Ia, III, IIIa, IV, and V) that define the covalent nucleotidyltransferase enzyme superfamily that includes ...

Total revenue of $59.3 million for the fiscal year ended December 31, 2024Expect double digit growth for total revenue in 20252025 to demonstrate ...

The study explains how the tRNA ligase complex (tRNA-LC), which is essential for digesting RNA molecules, is negatively regulated by the RTP801 factor. In a mouse model of Alzheimer's disease ...

RNA splicing is a modification of the nascent ... of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. Non-viral intron knock-ins for ...

reveal the mechanistic basis for the protective function of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. Understanding how RNA folds ...