Although the gene has been studied in other physiological and pathological contexts, its role in kidney disease had not been experimentally tested. In the study, "PPDPF preserves integrity of proximal ...

characterized by impaired reabsorption of cystine and dibasic amino acids in the renal proximal tubules. It exhibits a sex-dependent response, with males experiencing an earlier onset of stone ...

Sep. 18, 2024 — A team developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip -- OPTECs-on-Chip -- that mimics in vivo renal physiology more closely than ever before.

The kidney is a central organ of the mammalian ... promoting differentiation into proximal tubules. Finally, The most proximal part develops into glomeruli under the control of genes such as ...

The role of the kidney in blood glucose-level regulation was until recently underestimated. Renal gluconeogenesis, renal glucose uptake and tubular glucose reabsorption are the three ways of renal ...

Cysts, fibrosis, and tubular degeneration form the typical triad of pathologies leading to the gradual decline in kidney ...

The main symptom of kidney stones is pain in your back, abdomen, or side. Some other symptoms include cloudy urine, a burning sensation when you urinate, and nausea. Kidney stones are one of the ...

Diabetes-related kidney disease can worsen and lead to failure. You may experience many different symptoms, including lower back pain, fatigue, and nausea or vomiting. If you have kidney disease ...

Potassium is essential for kidney function. Too much or too little potassium can affect this function and lead to complications. Potassium plays a key role in a number of bodily processes ...

Clinical Considerations The clinical significance of hematuria can range from a minor incidental finding that does not require further work-up to a sign of significant disease such as a renal or ...