A research team led by Prof. HU Junjie from the Institute of Biophysics of the Chinese Academy of Sciences has uncovered a ...

For example, widely used whole cell immunogens preserve native membrane protein topology, but often lack sufficient concentrations of the target protein due to low expression levels, protein ...

Review Article Published: 11 March 2014 CTCF: an architectural protein bridging genome topology and function Chin-Tong Ong & Victor G. Corces Nature Reviews Genetics 15, 234–246 (2014) Cite this ...

In addition, this proposed topology is compatible with an interaction between the cytosolically oriented C-terminal end of the E protein and the C-terminal ends of the M or S proteins of SARS-CoV-2.

With the advance of cryo-EM single-particle reconstruction, more and more intermediate-resolution structures are available. It would be extremely useful if protein secondary structures and protein ...

More information: Sota Yagi et al, An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins, Nature Communications (2024). DOI: 10.1038/s41467-024-50013-9 ...

This mathematical model applies Topologic Data Analysis in a pioneering way in order to compare the three-dimensional structure of the target proteins of known medicines to SARS-CoV-2 coronavirus ...

Alan R. Fersht, Transition-State Structure as a Unifying Basis in Protein-Folding Mechanisms: Contact Order, Chain Topology, Stability, and the Extended Nucleus Mechanism, Proceedings of the National ...