Armed with just a magical paintbrush that he took with him, Mickey must stop a Mad Doctor who works closely with the Phantom Blot, earn back his half-brother's trust, and save the Cartoon Wasteland.

Using paint and thinner thrown from a magic paintbrush, Mickey must stop the Phantom Blot overlord, gain the trust of Oswald and save the day.

In "Mickey Mouse Outwits the Phantom Blot" Walt Disney's most famous creation stars in his first comic book. Floyd Gottfredson provided the art, and Minnie Mouse and Pluto make appearances.