Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

This figure illustrates the major signaling pathways and their intricate crosstalk in BC, focusing on the GPCR, RTKs, RAS/RAF/MEK1/2/ERK1/2, MAPK, HER2, PI3K/Akt/mTOR, Wnt/β-catenin, NF-κB ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and ...

Mutations in the oncogene KRAS are widespread in several human cancers, including pancreatic ductal adenocarcinomas (92%), colorectal carcinomas (49%) and lung adenocarcinomas (35%). These mutations ...

The review explores how signaling disruptions inside tumor cells are often behind these setbacks. The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR ...

A systematic review published in Discover Oncology explores the anticancer efficacy of medicinal plant extracts in treating Oral Squamous Cell Carcinoma (O | Plants And Animals ...

About Cutaneous Venous Malformations Cutaneous VMs are a rare genetic disease caused by mutations in genes that cause overactivation of the PI3K/mTOR signaling pathway, leading to dysfunctional veins ...

Early-onset CRC (EO-CRC) was associated with Flavonifractor plautii and increased bile acid, tryptophan, and choline ...

During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many intracellular pathways—series of signaling cascades within a cell—regulate these ...

The influenza A virus remains a major global health concern due to its role in seasonal outbreaks and its potential to trigger pandemics. Existing antiviral treatments are often limited by drug ...