The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

Second, methods to combine therapeutic approaches, including signal transduction inhibitors, radiation or chemotherapy, should be sought earlier in development. As the PI3K pathway can mediate ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the dysregulation of growth and inhibition of apoptosis that characterize advanced ...

A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." In this review article, Dinara Ryspayeva and colleagues from Brown ...

Patients with treated, PI3K-mutated early CRC had a 50-60% ... "This is the first trial to show that mutations in this specific signaling pathway, beyond the PIK3CA mutations, predict aspirin ...