One group showed that p53 controlled the progression of the cell cycle, but it wasn’t clear how. 24 Guillermina Lozano entered the p53 field as a postdoctoral fellow in Levine’s lab in 1985 and ...

Figure 2: A model of the p53–miR-34 network in regulating cell proliferation and cell death. We are only beginning to understand the realm of non-coding RNAs, whose representation in the genome ...

Conversely, the transcriptional targets of p53—a cell cycle regulator often mutated in cancers—such as CDKN1A and MDM2—were upregulated in these cells. In addition, markers of cellular ...

Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its ...

Sponsored by the biology department and the Michael J. Wolk Foundation, Alea Mills, a professor at Cold Spring Harbor ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.