Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Apr. 16, 2025 — Scientists have discovered how aging blood stem cells acquire mutations that give them a growth edge, creating fertile ground for the development of clonol hematopoiesis ...

This Protein Might Save Them ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.

KT-253 leads to potent p53 stabilization and induction of apoptosis To investigate the effect of KT-253 treatment on cell cycle progression, we quantified cell cycle distribution and viability in ...

1Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. 2The Melanoma and Skin Cancer Center, The Pennsylvania State University College of Medicine, ...

Of these, downregulation of Mdm2 (log2FC = -3.87, p.adj = 0.035) and Cdkn1a (log2FC = -3.22, p.adj = 0.002) in macrophages reflects impaired p53 regulation and compensatory cell cycle alteration. In ...

Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, Pritzker School of Medicine, University of Chicago, Chicago IL 60637, USA Tang Center for Herbal Medicine ...

These follicles repeatedly cycle through three distinct ... which triggered the P53 protein essential for regulating cell death. However, deletion of a P53 gene restored hair growth even in ...