One group showed that p53 controlled the progression of the cell cycle, but it wasn’t clear how. 24 Guillermina Lozano entered the p53 field as a postdoctoral fellow in Levine’s lab in 1985 and ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumorsFMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

Conversely, the transcriptional targets of p53—a cell cycle regulator often mutated in cancers—such as CDKN1A and MDM2—were upregulated in these cells. In addition, markers of cellular ...

Figure 2: A model of the p53–miR-34 network in regulating cell proliferation and cell death. We are only beginning to understand the realm of non-coding RNAs, whose representation in the genome ...

“Too much p53 in a normal cell will also induce apoptosis,” said ... this set of genes was enriched for functions related to cell cycle regulation, cell death, growth factor signaling, and immune ...

Sponsored by the biology department and the Michael J. Wolk Foundation, Alea Mills, a professor at Cold Spring Harbor ...

These follicles repeatedly cycle through three distinct ... which triggered the P53 protein essential for regulating cell death. However, deletion of a P53 gene restored hair growth even in ...