One target for such inhibition, the p38 mitogen-activated protein kinase (MAPK) signaling cascade, has a role in inflammation by mediating the cellular response to stress, pathogens, and cytokines.

These include therapeutic antibodies like ABX-IL-8 and HuMax-IL-8 (BMS-986253), CXCR1/CXCR2 inhibitors, and p38 MAPK inhibitors. The authors emphasize the importance of addressing potential ...

to activate neutrophils by activating p38 MAP kinase (MAPK). Similarly, formylated peptides released from bacteria and mitochondria activate the formyl peptide receptor-1 (FPR1) and attract ...