By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

A research group led by Gian Gaetano Tartaglia, Principal Investigator at the Italian Institute of Technology (IIT), ...

Mitochondria play a crucial role in maintaining energy balance and cellular health. Recent studies have shown that chronic stress in neuronal mitochondria can have far-reaching effects, not only ...

Excitability is a property of a cell, allowing it to respond to stimulation by rapid changes in membrane potential produced by ion fluxes across the plasma ... to dopamine neuron firing and ...

Integrins are heterodimeric structural proteins of the plasma membrane and are principally involved in cell–cell relationships in tissues and cell–extracellular matrix (ECM) protein interactions (1).

Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical ...

Unfortunately, the mechanisms regulating neuronal death in the affected areas remain largely unclear. Here, we found that deletion of the deubiquitinating enzyme Otubain-2 (OTUB2) significantly ...

Virginia [US], February 9 (ANI): Our biceps and brain cells might have more in common than we believed. According to a new study from the Lippincott-Schwartz Lab, a network of subcellular structures ...

To investigate the clinical relevance of plasma concentrations of neuron-specific enolase (NSE) in patients with severe cerebrovascular diseases, serial analyses were performed during the first 10 ...

Figure 1. Schematic diagram of α-Syn in SNARE (a complex composed of syntaxin-1A, VAMP2 and SNAP-25)-mediated membrane interaction. α-Syn's N-terminus forms two helices to interact with the plasma ...