N-myristoylation, the myristate modification of proteins, is linked to survival signaling and metabolism and is considered a potential target for AML. 2 Low expression of NMT2, which is involved in ...

Zelenirstat inhibits myristoylation in AML cell lines and patient samples, triggering apoptosis and cell death, including for AML stem cells, through multiple mechanisms. Oral zelenirstat for AML ...