This valuable study shows that locomotion-related modulations in the mouse visual cortex are not uniform but primarily affect neurons in muscarinic receptor-negative patches, which receive projections ...

Researchers from China Pharmaceutical University and Jiangsu Nhwa Pharmaceutical Co. Ltd. have synthesized azetidine-containing compounds acting as muscarinic M4 receptor positive allosteric ...

College of Plant Protection, Nanjing Agricultural University/State & Local Joint Engineering Research Center of Green Pesticide-Invention and Application, Nanjing 210095 Jiangsu, China ...

Non-clinical studies have demonstrated that omadacycline inhibits the binding of the neurotransmitter carbamylcholine to the M2 subtype of the muscarinic acetylcholine receptor, while remaining ...

Medicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Hungary National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary National ...

The AMPA group of brain receptors have mostly been assumed to be calcium impermeable and so were not thought to contribute to the calcium-dependent mechanisms underlying learning and memory.

At present no definitive medical treatment exists for acute pancreatitis. [9,10] Pirenzepine has shown encouraging positive responses and a low incidence of adverse effects when used to treat ...

Introduction: Cholinergic Receptor Muscarinic 1 (CHRM1) is a G protein-coupled acetylcholine (ACh) receptor predominantly expressed in the cerebral cortex. In a retrospective postmortem brain ...

The habenular-IPN circuit is rich in receptors for a neurotransmitter called acetylcholine. These receptors are also activated by nicotine, the addictive component of tobacco. Neurotransmitters are ...