Positive data from a pair of acute pain studies convinced the company that its drug, which works differently than existing ...

Data from the Centers for Disease Control and Prevention show there were about 107,000 drug overdose deaths in the United States in 2023. Of those, about 75%, or 81,000, involved opioids.

Chemokine receptors are GPCRs that regulate chemotactic migration of a wide variety of cells including immune and cancer cells. Most chemokine receptors contain features associated with the ability to ...

The recently published book, “Opioids 360: A Multidisciplinary Examination of an American Tragedy,” was edited by MU Criminal Justice Professors Sarah and Eric See and has chapters by 12 ...

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), originally ... looking to expand the label of their products to combat the opioid crisis. Early clinical work has shown that GLP-1RAs are ...

Co-prescribed stimulants, opioids linked to higher opioid doses Study analyzes millions of U.S. prescriptions over 10 years Date: February 21, 2025 Source: Ohio State University Summary: The ...

There are GLP-1 receptors in the brain’s mesolimbic system, which is inextricably linked to motivation and reward. This has piqued the interest of drug developers looking to expand the label of their ...

Stewart Clark, PhD, associate professor of pharmacology and toxicology, is principal investigator on a two-year, $420,000 grant titled “Preclinical Trial: Targeting the Neuropeptide S Receptor to Curb ...

The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the ...

In a surprising discovery, scientists have found that the heart possesses 'sweet taste' receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can ...

As an opioid itself, buprenorphine excites opioid receptors, preventing withdrawal symptoms. But unlike with other opioids, including methadone, which is also used to treat opioid addiction ...