Prof Malaspina, who is also the clinical academic lead at UCL’s Motor Neuron Disease Centre, explains that the first signs of ALS are normally muscle weakness or pain, twitching or speech ...

Dane, who is perhaps best known for his role as “Dr McSteamy” on Grey’s Anatomy ... disease that affects motor neurons, which control voluntary muscle movement. The rate at which ALS ...

The authors provide valuable insights into the candidate upstream transcriptional regulatory factors that control the spatiotemporal expression of selector genes and their targets for GABAergic vs ...

Skeletal muscle mass loss, a systemic manifestation of COPD, has garnered increasing attention, but its association with all-cause mortality in AECOPD remains unclear. This study aimed to ...

Furthermore, nobiletin supplementation suppressed muscle atrophy-related proteins, including p-4EBP1, TRIM63, and FBXO32, while promoting the phosphorylation of mTOR/AKT/p70S6K and FOXO3a in skeletal ...

Some cells, however, will land in a place to which they are very unlikely to ever adapt: Certain sites, such as the spleen and skeletal muscles, seem to resist metastasis, and there are many ...

This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advanced imaging techniques, electrical impedance myography, ...

We validated previous observations of neuronal cell number changes and muscle fiber distribution. We found that the increase in neuron cell number tends to lag behind the rapid expansion of somatic ...