Drug–drug interactions between antidiabetic agents and other pharmacological compounds may be two-sided. For those antidiabetic drugs that are metabolized via the CYP450 isoenzymes, concomitant ...

Vildagliptin has a halflife of about 90 minutes; however, ≥50% of DPP4 inhibition continues for more than 10 hours, allowing for once- or twice-daily dosing. Clinical trials have shown that ...