New AI model deciphers the code in proteins that tells them where to go
Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each performing a specialized function. Researchers have long known that the ...
eLife6d
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer
This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...
Nature20d
Mass testing of mutant enzymes involved in photosynthesis
The unexpected finding of several single-point mutants with an improved affinity for CO 2 demonstrates that the relationship between the amino-acid sequence of rubisco and its enzymatic function ...
Medscape20d
Is There a Link Between Liraglutide and Pancreatitis?
Diabetes Care. 2015;38(6):1058-1066. The safety profile of liraglutide is under continuous surveillance through meticulous routine pharmacovigilance, with any cases of pancreatitis being analyzed ...
C&EN20d
Effect of Lipidation on the Structure, Oligomerization, and Aggregation of Glucagon-like Peptide 1
Commercially available therapeutic lipidated GLP-1 analogues, semaglutide and liraglutide, have the great advantage of prolonged half-lives in vivo of hours and days instead of minutes as is the case ...
Frontiers21d
Applications of cell penetrating peptide-based drug delivery system in immunotherapy
Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating unnatural amino acids, and lipid conjugation ... the effects of ...
Health.com22d
11 Foods That Can Cause Acid Reflux (Heartburn)
Knowing foods that cause acid reflux can help you prevent and manage this condition. Common triggers include carbonated drinks, spicy foods, chocolate, and tomatoes. Acid reflux, also known as ...
unilad24d
Scientists say new evidence suggests 'we may have been wrong about the origin of life'
The study involved amino acids (Getty Images) Masel wrote: "The genetic code is an amazing system in which sequences of three nucleotides, known as codons, in a string of DNA or RNA are translated ...
World Scientific24d
DNN-PPI: A LARGE-SCALE PREDICTION OF PROTEIN–PROTEIN INTERACTIONS BASED ON DEEP NEURAL NETWORKS
Institute of Intelligent Machine, Hefei Institutes of Physical Science, Chinese Academy of Sciences, HeFei City, AnHui Province 230031, P. R. China University of Science and Technology of China, HeFei ...
C&EN25d
Biocatalytic Synthesis of Aryl and Heteroaryl γ-Hydroxy-α-amino Acids via an Aldolase–Transaminase One-Pot Reaction
Frontiers Science Center for Synthetic Biology (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China State Key Laboratory of Synthetic ...
The New York Times29d
Why Do TV Title Sequences Have So Much … Stuff?
I mean stuff. Matter. Material. Substances. Particularly in opening title sequences of TV series, where all manner of effluvia flows, wends and re-forms, through the magic of C.G.I., into shapes ...