As the researchers describe in a new paper in Cell Metabolism, the drug rapamycin restores leptin sensitivity to diet-induced obese mice, leading to significant loss of fat with only minimal effects ...

Leptin is an essential hormone that is closely ... The caffeine content may cause jitters or other side effects in some people. The supplement may not be suitable for everyone, so it’s important ...

It also increases the release of leptin. People with obesity may have a reduced sensitivity to CCK’s effects, which may lead to chronic overeating. This may further reduce CCK sensitivity ...

As the researchers describe in a paper in Cell Metabolism, the drug rapamycin restores leptin sensitivity to diet-induced ...

As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including infertility, impaired immune function, decreased insulin response and altered homeostasis).

Adiponectin levels were associated with increased likelihood of metabolic health improvements and lower risk for diabetes across 6 years.

To investigate further, the researchers tested the effects of rapamycin, an mTOR inhibitor, in four groups of mice: leptin-sensitive mice fed a low-calorie chow diet, mimicking people who remain ...

Clinical trials with r-Met-hu-leptin were also performed for the treatment of hypothalamic amenorrhea, where a 3-month administration resulted in the appearance of spontaneous menstrual cycles ...

Leptin is only one of many different mechanisms ... and so we can't be sure of their long-term effects. That said, the safety records for both Xenical and Meridia are good and the risk of side ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.