This paper entailed state-of-the-art experimental procedures to explore the binding of the Y674-R685 loop of the SARS-CoV-2 S-protein to three nAChRs – namely the human α4β2 and α7 subtypes ...

They constitute the largest class of LGICs and include nicotinic acetylcholine receptors (nAChR), γ-aminobutyric acid (GABA) receptors, 5-hydroxytryptamine-3 (5HT3) receptors, and glycine receptors.

The aim of this paper is to review the animal and human data to date, linking in utero smoke exposure to negative neurodevelopmental outcomes. It is known that nicotine from cigarette smoke exerts its ...

Bionomics has collaborated with MSD to identify novel α7 nAChR PAMs suitable for the treatment of cognitive disorders like Alzheimer’s DiseaseBased on the learnings from Bionomics’ candidate ...

Bionomics is advancing its lead drug candidate, BNC210, an oral, proprietary, selective negative allosteric modulator of the α7 nicotinic acetylcholine receptor, for the acute treatment of Social ...