News Medical on MSN1d
Adrenomedullin hormone as key driver of insulin resistance in obesity-linked type 2 diabetes
Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.
High levels of adrenomedullin found to promote obesity-associated insulin resistance
Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...
C&EN2d
If insulin can’t get into tissues, it can’t act
If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...
GEN5d
Obesity-Linked Hormone Adrenomedullin Disrupts Insulin Signaling
Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.
News Medical on MSN6d
How olive oil bioactives regulate genes linked to insulin resistance
Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
Nature6d
H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs
In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...
eLife5d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
Department of Genetics, Heersink School of Medicine, UAB Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, United States Department of Medicine, Division of Endocrinology ...