A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring immune cells by secondary messengers ...

Phosphorylated IRF3, together with NF-κB, translocates into the nucleus, initiating the expression of type I interferons (IFNs) and pro-inflammatory cytokines, thereby activating the innate immune ...

Inflammatory gene expression, including TLR2, TNF-α, MHC, CRP, TLR4, IRF3, complement pathway, IL-6, IFN-y, CD14, IL-10, TGF-β are altered in SCZ, while TNF-α, TLR4, IL-6, CD14 and IL-1 are altered in ...

These games generally receive all the hype and attention, but there are plenty of other initiatives helping the NFL expand around the world, with the International Player Pathway program being a ...

Immunostimulatory assays suggest condensate-specific activation of the IRF pathway via cGAS-STING signaling. This study provides a framework for developing biomolecular condensates with customizable ...

Both Samuel and David, as youths, fulfill God's will; David and Goliath (1 Sam. 17:26,34-37,47); David gains the heart of all (18:16); Saul's jealousy of David (18:9-11). And David said to Saul, Let ...

In senior school, all learners must take the following four core subjects, regardless of their preferred pathways: English, Kiswahili/Kenya Sign Language, Community Service Learning, and Physical ...