In the fall of 2014, a new Leica SP8 Laser Scanning Confocal Microscope came on line which was funded by a NSF-MRI grant to Larissa Williams, Matt Cote, Nancy Kleckner, and Travis Gould. As part of a ...

The best microscope allows you to experience the wonders of nature, beyond what the naked eye can detect. Just as the best telescopes let you explore outer space, microscopes give you access to inner ...

By contrast, we find that Ctf18-RFC is uniquely equipped to load PCNA onto the leading strand and show that this activity requires a direct interaction between Ctf18 and the CMG (Cdc45-MCM-GINS) ...

Encourage children to love science by showing them the world in miniature with some of the best microscopes for kids — here are our favorite models. The best microscopes for kids allow children ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Clustered regularly interspaced short ...

Cardiovascular diseases (CVDs) still maintain high morbidity and mortality globally. Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic acid (NA) metabolism ...

They play various regulatory roles in many biological processes. It is commonly agreed that G4 unwinding helicases play key roles in G4 metabolism and function, and these processes are closely related ...

Most replicative helicases are hexameric, ring-shaped motor proteins that translocate on and unwind DNA. Despite extensive biochemical and structural investigations, how their translocation activity ...

Assembly of bacterial ring-shaped hexameric replicative helicases on single-stranded (ss) DNA requires specialized loading factors. However, mechanisms implemented by ...