The achievement is not only a milestone in helicase research, but also a milestone in observing the dynamics of any enzyme at atomic resolution. While scientists have long known the importance of ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with DNA, the laboratories of KAUST Assistant Professor Alfredo De Biasio ...

The superfamily 1 (SF1) and SF2 enzymes are non-hexameric enzymes possessing both helicase and single-stranded DNA (ssDNA) translocase activities, as well as the ability to displace proteins from DNA.

Their work, published in Nature, focuses on proteins called helicases, which act as molecular motors to separate the two strands of DNA before cell division. What’s surprising isn’t just that ...