Neurodegenerative disorders have increasing incidence with limited treatment options. Approaches to target neuroinflammation in various neurodegenerative disorders, such as Alzheimer’s disease (AD), ...

Mechanical and biochemical stimuli demonstrate protective potential: ATP and moderate intensity exercise activate P2X7R ion channels, witch subsequently activate AMPK/mTOR-mediated autophagy for NLRP3 ...

During starvation-induced autophagy, ATG2A undergoes depalmitoylation as the balance between ZDHHC11-mediated palmitoylation and APT1-mediated depalmitoylation. Inhibition of ATG2A depalmitoylation ...