GEN12d
Making Strides Toward Off-the-Shelf CAR T Cell Therapy for Cancer
A new advance may make it possible to use off-the-shelf CAR T cells provided by healthy donors. The new approach studied in mice equipped CAR T cells with the viral protein Nef.
Medical Xpress on MSN15d
Viral protein Nef enables a step toward off-the-shelf CAR T cell therapy for cancer
By using a gene-editing tool called CRISPR, they could insert different viral proteins at a precise region in the genome of the CAR T cell called ... It worked in two ways: First, it reduced a protein ...
Hosted on MSN14d
Research Paves Way for Off-the-Shelf CAR T Cells for Cancer Treatment
CAR T cell therapy is one of the most promising new cancer treatments to emerge in recent years. It involves removing a ...
BMJ7d
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
Until now, data from genome-wide association studies (GWAS ... RA display significant risk allele frequency differences which are mainly confined to the HLA region. The data provide further support ...
jmg.bmj12d
Fine mapping MHC associations in Graves’ disease and its clinical subtypes in Han Chinese
Graves’ disease MHC HLA genome-wide association studies amino acid position This ... and genetic diversity challenges the determination of the causal functional variants in this region. All samples ...
gut.bmj7d
Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes
Design DNA samples from the eight patients underwent targeted exome ... providing a tertiary paediatric gastroenterology and endoscopy service for the Wessex region, and draws on a patient population ...
Activating complex regions of the genome to treat rare diseases: Researchers identify a a master epigenetic switch
Biomedical engineers at Duke University have demonstrated a promising new approach that could be used to treat a rare and ...