Hepatitis B virus (HBV) infection is associated with liver diseases, including chronic hepatitis, which notably increases the risk of cirrhosis and hepatocellular carcinoma (HCC) development. Although ...

Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...

The S ORF includes the preS1, preS2, and hepatitis B surface antigen (HBs) domains and encodes three envelope proteins, namely the large, middle, and small HBs antigens (HBsAg). The P and X ORFs ...

Part of the HBV polymerase gene flanking the YMDD motif ... M552I was detected before therapy in one patient but M552V became the domain strain after therapy. Until 52 weeks of therapy, serum ...

but selection of HBV polymerase mutants with enhanced replication by lamivudine treatment has also been reported. [19] In the present study, the mean values of HBV DNA levels of the five patients ...

Atomic force microscopy images show hepatitis B DNA in its natural state (left) and a zoomed-in look at how it wraps around human histones during an infection (right). The research team determined ...

The conflict between the primase activity and the DNA polymerase activity in a single protein with the same catalytic domain may be one reason for why DNA polymerases are generally unable to ...

Hepatitis B virus (HBV) is an important but difficult to study human ... We propose that the extension domain acts as a conformational switch with differential response options during viral infection.

The Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of RNA polymerase II and is essential for the ...