InFlectis BioScience SAS, a drug discovery company pioneering development of therapeutics harnessing the Integrated Stress ...

Promising results reported for IFB-088 in a Phase 2a clinical study in bulbar-onset ALS Patients. Biomarker evidence highlights ... which are involved in glutamate excitotoxicity that triggers calcium ...

Amyotrophic lateral sclerosis (ALS) is a fatal disease ... the detrimental role of astrocytes and reassess the frequently proposed hypothesis of glutamate-mediated excitotoxicity with respect to ...

Living in a disadvantaged community may decrease the length of time a person can survive with amyotrophic lateral sclerosis, or ALS, by over 30%, a study suggests. Similar studies have shown that ...

Yes, amyotrophic lateral sclerosis (ALS) can cause quadriplegia. ALS is a condition that causes gradual loss of muscle function. It can appear in various forms, including subtypes such as bulbar ...

At 2 years, more untreated controls died than those treated with IV edaravone. Treatment with IV edaravone for ALS was linked to a slowing of disease-progression milestones compared with no IV ...

In her final interview with CBS Evening News’ “Eye on America,” Barbara Goodfriend shared that she was diagnosed with ALS, or Amyotrophic Lateral Sclerosis, in April 2024. ALS — also known ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Several non-glutamate ion channels have been identified as potential therapeutic targets for cerebral ischemia in rodent models, including the following examples. In this review, we focus on the ...

IFB-088 (icerguastat) was safe and significantly slowed disease progression in certain people with ALS in a Phase 2 clinical trial.

Approved in 1995, Riluzole modestly prolongs survival in ALS patients by reducing the release of glutamate, a neurotransmitter that can be toxic to motor neurons at high levels. An important ...

The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift as the number of ... impaired DNA repair, excitotoxicity, mitochondrial dysfunction, oxidative stress, ...