Northwestern Medicine investigators have discovered previously unknown metabolic changes that may contribute to the ...

The female sex hormone estrogen, along with progesterone, appears to underlie a fundamental difference in how males and ...

Research from Weill Cornell Medicine has identified a molecular pathway linking omega-6 linoleic acid—a common dietary fat in ...

1 They pointed to prior research indicating that estrogen receptors are present in melanocytic lesions and that melanoma incidence is higher in women before menopause, suggesting a hormonal ...

The innovative approach targets human epidermal growth factor receptor 2-positive, estrogen receptor-negative (HER2-positive, ER-negative) breast cancer and has shown encouraging results in a ...

These mutations, often found in the ligand binding domain of the estrogen receptor, enable the receptor to remain active even without estrogen, allowing tumors to resist aromatase inhibitor therapy.

This resistance can occur due to mutations in the estrogen receptor gene (ESR1) or through the activation of alternative pathways that allow the cancer to continue growing even when hormone ...

Pfizer and Arvinas’ estrogen receptor (ER) degrader has failed a key part of its first phase 3 test, although the companies have pointed to success in a subpopulation to suggest the therapy ...

NEW HAVEN, Conn. and NEW YORK, March 11, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN) and Pfizer Inc. (NYSE: PFE) today announced positive topline results from the Phase 3 VERITAC-2 ...

license Estrogen effects in tissue are mediated in part through activation of the surface estrogen receptor GPER, a broadly expressed G protein-coupled receptor that impacts a wide range of normal and ...

Known as a “PROTAC,” or proteolysis-targeting chimera, it is designed to prod cells into trashing disease-linked proteins, such as the estrogen receptor. Arvinas is a leader in this field of targeted ...