Estimating equations like the MDRD equation play an important role in CKD diagnosis and treatment. “The CKD-EPI equation has lower bias, especially at higher estimated GFR,” Dr. Levey explained.

When eGFR was calculated using creatinine and cystatin C and without adjusting for race, adults with eGFR less than 60 mL/min/1.73 m2 had greater risk for dementia, but not for stroke, than those ...

Key takeaways: C-statistics were .750 during 2 years in a 4-variable model and .756 in an 8-year model. The risk equation outperformed the eGFR-based strategy across various net benefit thresholds.

For example, at an eGFR of 60 vs 80 mL/min/1.73m 2, eGFRcr failed to reveal increased death risks. The risks for all-cause mortality were increased 1.0- and 1.2-fold using eGFRcr and eGFRcr-cys ...

In first-line metastatic NSCLC patients with EGFR PACC mutations, the overall response rate by blinded independent central review was 81.8% (n=22; 95% CI, 59.7–94.8%) for those receiving the 240 ...