PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

All modern humans share DNA from two ancient populations that split 1.5 million years ago and reunited through interbreeding about 300,000 years ago. The genetic mixture is approximately 80% from one ...

and the RBD proteins were attached to a polyester substrate binding domain (SBD) formed by the C-terminus region of PHA depolymerase. The binding ability was evaluated over poly(3-hydroxybutyrate) ...

The complexity of eukaryotic DNA, with its long-range ... including transcription factor binding sites, exon-intron boundaries, and protein structural motifs. Sparse autoencoder techniques ...

Consistent with earlier findings, deletion of the YXXΦ motif ... domain of ORF3a in intracellular transport. Conversely, the C-terminal end of ORF3a might not be involved in the intracellular ...

Topoisomerase V is a unique topoisomerase that combines DNA repair and topoisomerase activities. The enzyme has an unusual arrangement, with a small topoisomerase domain followed by ... The structures ...

Overexpression of a catalytically inactive PKR mutant (K296H) accelerates viral protein accumulation and increases virus titer, whereas a K64E substitution in the dsRNA binding site abolishes this ...

Transcription factors are crucial regulators of gene expression. Accurate quantitative definition of their intrinsic DNA binding preferences is critical to understanding their biological function.