Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States David H. Koch Institute for Integrative Cancer Research, Massachusetts ...

Each IAA addition increases the monoisotopic mass of a peptide by 57.07 Da. In order to establish the successful combinatorial use of RiPP pathways, we first selected a group of cyclic antimicrobial ...

Scientists investigate various compounds to discover new antibiotics, one class of which is antimicrobial peptides (AMPs), produced by organisms in response to bacterial infections. Commercially ...

We thank Xiaoju Li, Haiyan Yu, Xiaomin Zhao, and Sen Wang from Core Facilities for Life and Environmental Sciences of Shandong University for their assistance in X-ray diffraction. We also thank the ...

Cyclic peptides, which combine characteristics of both small molecules and proteins, have emerged as significant molecules for regulating protein–protein interactions (PPIs). Recent studies have ...

Our expertise extends to: Long peptides: Optimised strategies for the synthesis of long and challenging sequences with high purity. Cyclic peptides: Specialised techniques for head-to-tail cyclisation ...

In collaboration with GSK, you will leverage recent advances in our groups in covalent cyclic peptide discovery and peptide and covalent fragment screening in cells. You will have the opportunity to ...

Antimicrobial peptides (AMPs) are a new class of promising antibacterial agents. We prepared electrospinning chitosan (CS)-polyethylene oxide (PEO) nanofiber membranes containing different ...

TABLE 1. In Vitro antimicrobial activities of marcin-18 and its homologs compared with other peptides and antibiotics. Effect of Salt and pH on Activity of Marcin-18 and Its Homologs Marcin-18 and its ...