Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Nishikyo-ku, Kyoto 615-8510, Japan ...

Specifically, the binding preferences of foldamers designed for human IAPP were not fully accounted for by conformational selection, unlike those of β-breaking peptides designed to mimic IAPP ...

The 2 Å crystal structure reported here of the collagen-like model peptide, T3-785, provides the first visualization of how the sequence of collagen defines distinctive local conformational ...

The division employs a range of techniques in cellular, molecular, and structural biology together with animal models and LC-MS based lipid profiling with the goal to understand the role of ...

To monitor ligand-induced conformational changes in the TM domain, we performed experiments with truncated VEGFR-2 constructs carrying fluorescent proteins attached via flexible (GGS) 5 linkers to the ...

In this paper, we set out to gain further insights into the proteolytic mechanism of γ-secretase by using two complementary approaches to sample the conformational landscape of its catalytic subunit.