The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.

Histone proteins provide essential structural support for DNA in chromosomes, acting as spools around which DNA strands wrap. These proteins have been well studied, but most current tools to study ...

The histone, in turn, forms large loops. So the DNA is much, much longer than the chromosome it makes up. The DNA of one of a fruit fly's chromosomes, for example, would be 12 times longer than ...

To convert a piece of cloned DNA into a centromere-containing human artificial chromosome (HAC), an array of repeated ... LacO domains (1), and incorporates the specialized centromeric histone CENP-A ...

They discovered that despite relatively weak binding by an essential protein—histone variant CENP-A/Cse4—to DNA, other proteins are recruited to one specific site in the center of the chromosome ...

Novel technology enables discovery, which could help predict tumour recurrence Researchers from the Fred Hutch Cancer Centre, ...

Evaluating histone H3 lysine-4 methylation in animals ... because of its simple genetics and the fact that its genetic elements are incredibly similar to that of humans. With Drosophila as their ...

In particular, it explains that humans have one fewer chromosome pair in their cells than apes, due to a mutation found in chromosome number 2 that caused two chromosomes to fuse into one.

This course provides and overview of epigenetic mechanisms, including DNA methylation, histone modifications, chromosome structure, and nuclear organization. We will discuss how molecules help ...