Furthermore, AD is associated with oxidative stress, impaired mitochondrial structure and function ... Dipeptidyl peptidase-4 inhibitors (DPP-4i s) include sitagliptin, vildagliptin, saxagliptin, ...

Purpose: The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, and role in therapy of vildagliptin for the treatment of type 2 diabetes mellitus were reviewed.

Objective: We sought to evaluate the efficacy and safety of vildagliptin, a new dipeptidyl peptidase-4 inhibitor, added to metformin during 24 weeks of treatment in patients with type 2 diabetes.

Researchers have profiled the molecular structure and features of a key part of the deadly Nipah virus. Experiments in cells showe how changes in the viral polymerase -- a protein involved in ...

The way the body ages could be more resilient than previously thought, a new study suggests.

Collagen, the body's most abundant protein, has long been viewed as a predictable structural component of tissues. However, a ...

In a new study published in Nature, University of Missouri researchers have, for the first time, revealed the specific shape ...

When you first enter a new world, you can either spawn near a structure or find one while exploring any of the three dimensions. While finding some can be quite easy, others are extremely hard to ...

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...

In a new study published in Nature, University of Missouri researchers have, for the first time, revealed the specific shape ...