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eLife21d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...
eLife21d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
TFEB overexpression or pharmacological activation of TFEB ameliorates cholesterol accumulation in U18666A-induced HeLa NPC1 model. A working scheme to illustrate that small-molecule TFEB agonist ...
C&EN1mon
Inhaled Lead Nanoparticles Enter the Brain through the Olfactory Pathway and Induce Neurodegenerative Changes Resembling Tauopathies
Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno 602 00, Czech Republic ...
Frontiers9mon
Circuit dynamics of the olfactory pathway during olfactory learning
Inputs from olfactory bulb (OB) and piriform cortex (Pir) reach LEC layer I; Reelin (RE) positive cells project to medial entorhinal cortex (MEC) and dentate gyrus (DG) (shown in dark red); Calbindin ...
Frontiers1y
Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder
The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD). Individuals with ASD typically have impairments in hippocampus-dependent learning, memory, language ability, ...