High-salt diet linked to depression: Protein IL-17A plays key role in mice study
A new study published in The Journal of Immunology found that a high-salt diet (HSD) induces depression-like symptoms in mice ...
eLife15d
Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice
This important study utilizes humanized mice, in which human immune cells are introduced into immune-deficient mice, to provide convincing evidence that two helper CD4 T-cell subsets, T-follicular ...
C&EN21d
Synergistic Antitumor Immunotherapy via Mitochondria Regulation in Macrophages and Tumor Cells by an Iridium Photosensitizer
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, ...
BMJ29d
Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression
1 University of Leeds Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK Background The human enthesis conventional T cells are poorly characterised. Objectives To study the biology ...
eLife1y
Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent of the keratinocyte-derived malignancies with actinic keratosis (AK) as a precancerous lesion. To comprehensively delineate the ...
Frontiers2y
Palbociclib impairs the proliferative capacity of activated T cells while retaining their cytotoxic efficacy
The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib is an emerging cancer therapeutic that just recently gained Food and Drug Administration approval for treatment of estrogen receptor ...
Frontiers6y
Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis
Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the ...