In mice modeled to develop late-onset HPP as adults rather than infants, the gene therapy was more effective on female mice, and in females the improvements in bone and teeth were achieved with a ...

Osteoclastic bone resorption is regulated by the RANKL/osteoprotegerin/RANK pathway, while osteoblastic bone formation is controlled by canonical Wnt signaling. Antiresorptive bisphosphonates ...

alteration in gene expression, and changes in signaling pathways. Key genetic and pathway alterations include the amplification and/or mutation of the androgen receptor, the loss of Rb, PTEN, and p53, ...

Expert Rev Endocrinol Metab. 2009;4(6):639-650. © 2009 Expert Reviews Ltd. Cite this: Bone Signaling Pathways and Treatment of Osteoporosis - Medscape - Nov 01, 2009 ...

Anticipation is growing for the film adaptation of young adult hit novel "Children of Blood and Bone." ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone ... in gene expression, particularly in ferroptosis-related pathways.

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis ... in gene expression, particularly in ferroptosis-related pathways.

Researchers have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some men don't produce ...