In two new papers, researchers from The Jackson Laboratory (JAX) report the successful use of two approaches—gene therapy and ...

In a paper published in the Journal of Bone and Mineral Research, Millán's team and collaborators added additional weight to prior preclinical evidence of the safety and effectiveness of a gene ...

Bone does not just grow in any which way—rather, the bone cells respond to external forces. If bones are subjected to targeted mechanical loading as they heal following a fracture, they can ...

In mice modeled to develop late-onset HPP as adults rather than infants, the gene therapy was more effective on female mice, and in females the improvements in bone and teeth were achieved with a ...

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“We believe the next evolution in treating HPP will be a gene therapy in which a single injected dose will provide a lifelong treatment for patients,” said Millán. In a paper published January 12, ...

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Osteoclastic bone resorption is regulated by the RANKL/osteoprotegerin/RANK pathway, while osteoblastic bone formation is controlled by canonical Wnt signaling. Antiresorptive bisphosphonates ...

The structural integrity of bones has been attributed to bone remodeling—a highly regulated ... we carried out in-depth analyses of gene expression patterns of cells derived from mice with ...