The EMBO Journal22d
Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein synthesis is an essential process, ...
The EMBO Journal26d
Francesco Amaldi (1939-2024) – a pioneer in RNA research
Francesco Amaldi died at the age of 84 in Rome on August 13, 2024, assisted by his beloved wife Paola and their children Andrea and Ilaria together with the grandchildren Jaco, Emilio, and Elena. He ...
eLife1mon
Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling
Our findings identify EZRIN as a critical regulator of autophagy via TSC complex in response to EGF stimuli and establish the central role of early endosomal signaling in the regulation of mTORC1.
Frontiers3y
Organization of Presynaptic Autophagy-Related Processes
Figure 4. Inventory of autophagy-related proteins detected in presynaptic boutons and their relevant sites of action (for details see text and Table 1). Bsn, Bassoon; CAZ, cytomatrix at the active ...
Frontiers4y
The Small GTPase Rab5c Exerts Bi-Function in Singapore Grouper Iridovirus Infections and Cellular Responses in the Grouper, Epinephelus coioides
The Rab5-to-Rab7 switch machinery executes conversion from the EE to late endosome (LE). In addition, Rab5 is also associated with immune responses, such as phagocytosis and autophagy (12). It has ...
eLife7y
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
Pharmacological inhibition or knock-down of PIP4Kγ modulates the equilibrium between phosphatidylinositide (PI) species within the cell and increases basal autophagy, reducing the total amount of mHtt ...